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(2012) 46:S12

The Mountainous West, reviewed by Marshall E

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Response: We thank all commenters for their careful consideration of the proposed approach to stratify the APCM codes, and we appreciate commenters' suggestions for specific types of beneficiaries who may require intensive care management resource utilization and warrant an additional APCM code level, including beneficiaries with complex illness

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Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms